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New Labdane Diterpenes and Their Glycoside Derivatives from the Roots of Isodon adenantha
Author(s) -
Wu LaBin,
Xiao ChaoJiang,
Jiang Xue,
Qiu Lin,
Dong Xiang,
Jiang Bei
Publication year - 2015
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201400287
Subject(s) - labdane , chemistry , diterpene , glycoside , stereochemistry , lignan , aconitine , two dimensional nuclear magnetic resonance spectroscopy , organic chemistry , chromatography
Two new labdane‐type diterpenes (adenanthic acids A and B; 1 and 2 , resp.) and three new labdane diterpene glycosides (adenanthosides A–C; 3 – 5 , resp.) were isolated from the roots of Isodon adenantha , together with 23 known constituents including seven diterpenoids ( 6 – 12 ), eight triterpenoids ( 13 – 20 ), one lignan glycoside ( 21 ), six steroids ( 22 – 27 ), and one ceramide ( 28 ). Their structures were elucidated by spectroscopic methods including extensive 2D‐NMR techniques. Cytotoxicity and antibacterial activities of the samples were measured by the MTT method and the filter paper disc agar diffusion method. But none of them showed significant activities.