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Two New Hydronaphthoquinones from Sinningia aggregata (Gesneriaceae) and Cytotoxic Activity of Aggregatin D
Author(s) -
Verdan Maria Helena,
Mera de Souza Lauro,
Ernesto de Carvalho João,
Vendramini Costa Débora B.,
Salvador Marcos José,
Barison Andersson,
Alves Stefanello Maria Élida
Publication year - 2015
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201400281
Subject(s) - gesneriaceae , hacat , chemistry , stereochemistry , cell culture , tyrosol , cancer cell lines , cytotoxic t cell , traditional medicine , botany , cancer cell , biochemistry , biology , cancer , in vitro , antioxidant , medicine , genetics
Two new hydronaphthoquinones, aggregatins E and F ( 1 and 2 , resp.) were isolated from the tubers of Sinningia aggregata ( Ker‐Gawl .) Wiehler (Gesneriaceae), along with twelve known compounds aggregatin D ( 3 ), tectoquinone ( 4 ), 1‐hydroxy‐2‐methylanthraquinone ( 5 ), icosyl ferulate ( 6 ), pustuline ( 7 ), 1,6‐dihydroxy‐2‐methylanthranquinone ( 8 ), 6‐hydroxy‐2‐methylanthraquinone ( 9 ), 7‐hydroxy‐2‐methylanthraquinone ( 10 ), tyrosol ( 11 ), halleridone ( 12 ), calceolarioside B ( 13 ), and cornoside ( 14 ). All compounds were identified by analysis of spectroscopic and spectrometric data. Compounds 3, 4 , and 10 had already been reported in this species. Compounds 2 and 3 were evaluated against several tumor cell lines, but only 3 exhibited activities against UACC‐62, 786‐0 and OVCAR‐3 cell lines, with IC 50 values of 12.3, 12.8 and 0.3 μg/ml, respectively, without toxic effects on non‐cancer cell line HaCat (human keratinocyte).
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