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Lupane‐ and Friedelane‐Type Triterpenoids from Celastrus stylosus
Author(s) -
Ying YouMin,
Li CuiYu,
Chen Yan,
Xiang JiaGui,
Fang Ling,
Yao JianBiao,
Wang FaSong,
Wang RuWei,
Shan WeiGuang,
Zhan ZhaJun
Publication year - 2015
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201400269
Subject(s) - triterpenoid , chemistry , stereochemistry , chemical constituents , cancer cell lines , terpene , oleanane , traditional medicine , triterpene , cancer cell , cancer , biology , chromatography , medicine , genetics , alternative medicine , pathology
Two new triterpenoids, 30‐hydroxylup‐20(29)‐ene 3 β ‐caffeate ( 1 ) and 24‐nor‐friedelan‐6 α ,10‐dihydroxy‐1,2‐dioxo‐4,7‐dien‐29‐oic acid ( 2 ), together with eight known compounds 3 – 10 , were isolated from the roots of Celastrus stylosus. The structures of these compounds were elucidated on the basis of spectroscopic analyses. To the best of our knowledge, this represents the first study on the chemical constituents of C. stylosus. The antiproliferative activities of the triterpenoids against six human cancer cell lines (PANC‐1, A549, PC‐3, HepG2, SGC‐7901, and HCCLM3) were evaluated. Compounds 3, 4 , and 10 exhibited comparable activities against PC‐3 and HCCLM3 cell lines as the positive control taxol.