Premium
Diterpene Constituents of Euphorbia exigua L. and Multidrug Resistance Reversing Activity of the Isolated Diterpenes
Author(s) -
Rédei Dóra,
Boros Klára,
Forgo Peter,
Molnár Joseph,
Kele Zoltán,
Pálinkó István,
Pinke Gyula,
Hohmann Judit
Publication year - 2015
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201400260
Subject(s) - diterpene , multiple drug resistance , euphorbia , phytochemical , chemistry , exigua , terpenoid , traditional medicine , stereochemistry , biochemistry , biology , botany , gene , spodoptera , antibiotics , medicine , recombinant dna
Phytochemical investigation of the MeOH extract obtained from the aerial parts of the annual weed Euphorbia exigua L. resulted in the isolation of two novel ( 1, 2 ) and one known ( 3 ) jatrophane diterpenes. Their structures were established by extensive 1D‐ and 2D‐NMR spectroscopy and HR‐ESI‐MS. The isolated compounds were evaluated for multidrug resistance (MDR) reversing activity on human MDR gene‐transfected L5178 mouse lymphoma cells; and all three compounds were found to modulate the intracellular drug accumulation.