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New 3,4‐Secocycloartane and 3,4‐Secodammarane Triterpenes from the Ecuadorian Plant Coussarea macrophylla
Author(s) -
Gilardoni Gianluca,
Chiriboga Ximena,
Vita Finzi Paola,
Vidari Giovanni
Publication year - 2015
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201400182
Subject(s) - terpene , chemistry , rubiaceae , bark (sound) , stereochemistry , traditional medicine , botany , biology , medicine , ecology
Coussarea macrophylla ( Mart .) Müll.Arg . (Rubiaceae) was collected in Ecuador, and the bark was extracted with AcOEt. Chromatographic separation afforded six novel 3,4‐secocycloartane and 3,4‐secodammarane triterpenes, named macrocoussaric acids A–F, together with the known metabolites secaubryenol and 3,4‐secodammara‐4(28),20,24‐triene‐3,26‐dioic acid. The structures of the new compounds were determined on the basis of their spectroscopic data. This is the first report of 3,4‐secocycloartane and 3,4‐secodammarane triterpenes occurring in a Coussarea species. Macrocoussaric acids A and B ( 2 and 3 , resp.) were found to be moderately cytotoxic against five different tumor cell lines.