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Insecticidal and Repellant Activities of Polyacetylenes and Lactones Derived from Atractylodes lancea Rhizomes
Author(s) -
Chen HaiPing,
Zheng LiShi,
Yang Kai,
Lei Ning,
Geng ZhuFeng,
Ma Ping,
Cai Qian,
Du ShuShan,
Deng ZhiWei
Publication year - 2015
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201400161
Subject(s) - rhizome , atractylodes , chemistry , zingiber officinale , petroleum ether , traditional medicine , botany , chromatography , biology , extraction (chemistry) , medicine , alternative medicine , pathology , traditional chinese medicine
During a screening program for new agrochemicals from Chinese medicinal herbs and local wild plants, the petroleum ether (PE) extract of Atractylodes lancea ( Thunb. ) rhizomes was found to possess repellent and contact activities against Tribolium castaneum adults. Bioactivity‐directed chromatographic separation of PE extract on repeated silica‐gel columns led to the isolation of two polyacetylenes, atractylodin and atractylodinol ( 1 and 2 , resp.), and two lactones, atractylenolides II and III ( 3 and 4 , resp.). The structures of the compounds were elucidated based on NMR spectra. The four isolated compounds were evaluated for their insecticidal and repellent activities against T. castaneum. Atractylodin exhibited strong contact activity against T. castaneum adults with a LD 50 value of 1.83 μg/adult. Atractylodin and atractylenolide II also possessed strong repellenct activities against T. castaneum adults. After 4‐h exposure, >90% repellency was achieved with atractylodin at a low concentration of 0.63 μg/cm 2 . The results indicated that atractylodin ( 1 ) and atractylenolide II ( 3 ) have a good potential as a source for natural repellents, and 1 has the potential to be developed as natural insecticide.