Recent Results in the Search for New Molecules with Ambergris Odor

The synthesis of new odorant molecules is still a challenging task for the fragrance chemist, because now as ever it is difficult to predict the odor properties of small organic molecules. Therefore, certain tools, such as, e.g. , lead‐structure optimization of existing odorants, are helpful techniques. In this article, we describe the synthesis and the odor properties of a new molecule derived by the so‐called ‘ seco ’ lead‐structure optimization of the ambergris compound Ambroxide ® . Based on these results, more representatives with similar structures have been synthesized and evaluated for their olfactory properties.