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Sesquiterpenoids with Anti‐MDR Staphylococcus aureus Activities from Ferula ferulioides
Author(s) -
Liu Tao,
Wang Shuangying,
Xu Lili,
Fu Wei,
Gibbons Simon,
Mu Qing
Publication year - 2015
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201400150
Subject(s) - staphylococcus aureus , chemistry , minimum inhibitory concentration , antibacterial activity , antimicrobial , traditional medicine , sesquiterpene , stereochemistry , microbiology and biotechnology , bacteria , biology , organic chemistry , medicine , genetics
Abstract Seven new sesquiterpenoids together with 21 known sesquiterpenoid derivatives were isolated from the medicinal plant Ferula ferulioides ( Steud .) Korovin . Their structures were elucidated by comprehensive spectroscopic analyses and chemical transformations. The isolated compounds were evaluated for their antibacterial activities against a panel of bacteria including multidrug‐resistant (MDR) and methicillin‐resistant Staphylococcus aureus (MRSA), displaying minimum inhibitory concentration ( MIC ) values in the range of 0.5–128 mg/l.