Sesquiterpenoids with Anti‐MDR  Staphylococcus aureus  Activities from  Ferula ferulioides | Zendy

Liu Tao | Zendy; Wang Shuangying | Zendy; Xu Lili | Zendy; Fu Wei | Zendy; Gibbons Simon | Zendy; Mu Qing | Zendy

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Sesquiterpenoids with Anti‐MDR Staphylococcus aureus Activities from Ferula ferulioides

Author(s) -

Liu Tao,

Wang Shuangying,

Xu Lili,

Fu Wei,

Gibbons Simon,

Mu Qing

Publication year - 2015

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.201400150

Subject(s) - staphylococcus aureus , chemistry , minimum inhibitory concentration , antibacterial activity , antimicrobial , traditional medicine , sesquiterpene , stereochemistry , microbiology and biotechnology , bacteria , biology , organic chemistry , medicine , genetics

Seven new sesquiterpenoids together with 21 known sesquiterpenoid derivatives were isolated from the medicinal plant Ferula ferulioides ( Steud .) Korovin . Their structures were elucidated by comprehensive spectroscopic analyses and chemical transformations. The isolated compounds were evaluated for their antibacterial activities against a panel of bacteria including multidrug‐resistant (MDR) and methicillin‐resistant Staphylococcus aureus (MRSA), displaying minimum inhibitory concentration ( MIC ) values in the range of 0.5–128 mg/l.

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