Cochlioquinone Derivatives with Apoptosis‐Inducing Effects on HCT116 Colon Cancer Cells from the Phytopathogenic Fungus  Bipolaris luttrellii  L439 | Zendy

Qi QiuYue | Zendy; Huang Li | Zendy; He LuWei | Zendy; Han JunJie | Zendy; Chen Quan | Zendy; Cai Lei | Zendy; Liu HongWei | Zendy

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Cochlioquinone Derivatives with Apoptosis‐Inducing Effects on HCT116 Colon Cancer Cells from the Phytopathogenic Fungus Bipolaris luttrellii L439

Author(s) -

Qi QiuYue,

Huang Li,

He LuWei,

Han JunJie,

Chen Quan,

Cai Lei,

Liu HongWei

Publication year - 2014

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.201400106

Subject(s) - apoptosis , fungus , chemistry , downregulation and upregulation , cytochrome c , mitochondrion , stereochemistry , bcl xl , cancer cell , protein data bank (rcsb pdb) , biochemistry , cancer , programmed cell death , biology , gene , botany , genetics

A new cochlioquinone derivative, cochlioquinone F ( 1 ), as well as three known compounds, anhydrocochlioquinone A ( 2 ), isocochlioquinone A ( 3 ), and isocochlioquinone C ( 4 ), were isolated from the PDB (potato dextrose broth) culture of the phytopathogenic fungus Bipolaris luttrellii. The structure of 1 was elucidated on the basis of NMR techniques. The apoptosis‐inducing effects of compounds 1 – 4 were evaluated against HCT116 cancer cells. Compound 2 exhibited the strongest activity in inducing apoptosis on HCT116 cells within the range of 10–30 μ M . In addition, the caspase activation, the release of cytochrome c from mitochondria, and the downregulation of Bcl‐2 protein in HCT116 cells treated with compound 2 were detected.

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