Microjaponin, A New Dihydroagarofuranoid Sesquiterpene from the Stem of  Microtropis japonica  with Antituberculosis Activity | Zendy

Chen JihJung | Zendy; Kuo WenLung | Zendy; Chen IhSheng | Zendy; Peng ChienFang | Zendy; Sung PingJyun | Zendy; Cheng MingJen | Zendy; Lim YunPing | Zendy

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Microjaponin, A New Dihydroagarofuranoid Sesquiterpene from the Stem of Microtropis japonica with Antituberculosis Activity

Author(s) -

Chen JihJung,

Kuo WenLung,

Chen IhSheng,

Peng ChienFang,

Sung PingJyun,

Cheng MingJen,

Lim YunPing

Publication year - 2014

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.201400066

Subject(s) - sesquiterpene , chemistry , in vitro , japonica , mycobacterium tuberculosis , stereochemistry , botany , biochemistry , tuberculosis , biology , medicine , pathology

A new dihydroagarofuran‐based sesquiterpene, microjaponin ( 1 ), was isolated from the stem of Microtropis japonica. Its structure was determined by in‐depth spectroscopic and mass‐spectrometric analyses. Microjaponin ( 1 ) exhibited potent in vitro antituberculosis activity, with an MIC value of 12.5 μg/ml against Mycobacterium tuberculosis H 37 Rv.

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