Premium
Microjaponin, A New Dihydroagarofuranoid Sesquiterpene from the Stem of Microtropis japonica with Antituberculosis Activity
Author(s) -
Chen JihJung,
Kuo WenLung,
Chen IhSheng,
Peng ChienFang,
Sung PingJyun,
Cheng MingJen,
Lim YunPing
Publication year - 2014
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201400066
Subject(s) - sesquiterpene , chemistry , in vitro , japonica , mycobacterium tuberculosis , stereochemistry , botany , biochemistry , tuberculosis , biology , medicine , pathology
A new dihydroagarofuran‐based sesquiterpene, microjaponin ( 1 ), was isolated from the stem of Microtropis japonica. Its structure was determined by in‐depth spectroscopic and mass‐spectrometric analyses. Microjaponin ( 1 ) exhibited potent in vitro antituberculosis activity, with an MIC value of 12.5 μg/ml against Mycobacterium tuberculosis H 37 Rv.