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Cytotoxic Compounds from the Leaves of Garcinia polyantha
Author(s) -
Lannang Alain Meli,
Tatsimo Simplice J. N.,
Fouotsa Hugues,
Dzoyem Jean Paul,
Saxena Ajit Kumar,
Sewald Norbert
Publication year - 2014
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201300401
Subject(s) - chemistry , stereochemistry , triterpene , clusiaceae , cytotoxic t cell , garcinia , two dimensional nuclear magnetic resonance spectroscopy , sterol , benzophenone , derivative (finance) , terpene , friedelin , xanthone , biochemistry , triterpenoid , botany , organic chemistry , biology , in vitro , medicine , alternative medicine , pathology , cholesterol , economics , financial economics
A new compound, named banganxanthone C (=12‐(1,1‐dimethylprop‐2‐en‐1‐yl)‐5,10‐dihydroxy‐9‐methoxy‐2‐methyl‐2‐(4‐methylpent‐3‐en‐1‐yl)‐2 H ,6 H ‐pyrano[3,2‐ b ]xanthen‐6‐one; 4 ), together with five known compounds, were isolated from the leaves of Garcinia polyantha. The structures of the compounds were elucidated on the basis of 1D‐ and 2D‐NMR spectroscopy. Among the known compounds, two were xanthones, one was a pentacyclic triterpene, one sterol, and one benzophenone derivative. Isoxanthochymol ( 2 ) and 4‐[(2 E )‐3,7‐dimethylocta‐2,6‐dien‐1‐yl]‐1,5,8‐trihydroxy‐3‐methoxy‐9 H ‐xanthen‐9‐one ( 3 ) exhibited significant antiproliferative activity against the leukemia cell line TPH‐1 with IC 50 inhibition values of 1.5 and 2.8 μg/ml, respectively. The cytotoxic activity was found to be related to apoptosis induction.