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Suppression of Inflammatory Cytokine Production by ar ‐Turmerone Isolated from Curcuma phaeocaulis
Author(s) -
Oh Sera,
Han A Rheum,
Park Hye Ryeon,
Jang Eun Jung,
Kim Hyo Kyeong,
Jeong Mi Gyeong,
Song Hyuna,
Park Gun Hwa,
Seo Eun Kyoung,
Hwang Eun Sook
Publication year - 2014
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201300397
Subject(s) - rhizome , chemistry , zingiberaceae , curcuma , cytokine , proinflammatory cytokine , t cell , stimulation , stereochemistry , pharmacology , inflammation , traditional medicine , immunology , immune system , endocrinology , biology , medicine
Rhizomes of Curcuma phaeocaulis Valeton (Zingiberaceae) have traditionally been used for controlling inflammatory conditions. Numerous studies have aimed to isolate and characterize the bioactive constituents of C. phaeocaulis. It has been reported that its anti‐inflammatory properties are a result of cyclooxygenase‐2 inhibition; however, its effect on the T‐cell function remains to be elucidated. In this study, four known sesquiterpenoids, viz., ar ‐turmerone (TM), germacrone (GM), (+)‐(4 S ,5 S )‐germacrone‐4,5‐epoxide (GE), and curzerenone (CZ), were isolated from C. phaeocaulis rhizomes and evaluated for their effects on the CD4 + T‐cell function. While GM, GE, and CZ had no effect on the activation of splenic T cells or CD4 + T cells, TM suppressed the interferon (IFN)‐ γ production, without affecting the interleukin (IL)‐4 expression. TM also decreased the expression of IL‐2 in CD4 + T cells, but did not change their cell‐division rates upon stimulation. These results suggest that TM, a major constituent of C. phaeocaulis rhizomes selectively exerts potent anti‐inflammatory effects via suppression of the inflammatory cytokines IFN‐ γ and IL‐2.