Garcimultiflorone G, a Novel Benzoylphloroglucinol Derivative from  Garcinia multiflora  with Inhibitory Activity on Neutrophil Pro‐Inflammatory Responses | Zendy

Ting ChiaWei | Zendy; Hwang TsongLong | Zendy; Chen IhSheng | Zendy; Cheng MingJen | Zendy; Sung PingJyun | Zendy; Yen MingHong | Zendy; Chen JihJung | Zendy

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Garcimultiflorone G, a Novel Benzoylphloroglucinol Derivative from Garcinia multiflora with Inhibitory Activity on Neutrophil Pro‐Inflammatory Responses

Author(s) -

Ting ChiaWei,

Hwang TsongLong,

Chen IhSheng,

Cheng MingJen,

Sung PingJyun,

Yen MingHong,

Chen JihJung

Publication year - 2014

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.201300278

Subject(s) - chemistry , superoxide , elastase , derivative (finance) , garcinia , inhibitory postsynaptic potential , stereochemistry , cytochalasin , cytochalasin b , biochemistry , traditional medicine , in vitro , enzyme , cell , biology , medicine , cytoskeleton , neuroscience , financial economics , economics

A novel benzoylphloroglucinol derivative, garcimultiflorone G ( 1 ), was isolated from the fruits of Garcinia multiflora. The structure of 1 was determined through extensive 1D‐ and 2D‐NMR, and MS analyses. Garcimultiflorone G ( 1 ) showed inhibitory effects against superoxide anion (O $\rm{{_{2}^{{^\cdot} -}}}$ ) generation and elastase release by human neutrophils in response to formyl‐ L ‐methionyl‐ L ‐leucyl‐ L ‐phenylalanine/cytochalasin B (fMLP/CB), with IC 50 values of 6.97±1.56 and 11.70±1.58 μ M , respectively.

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