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Garcimultiflorone G, a Novel Benzoylphloroglucinol Derivative from Garcinia multiflora with Inhibitory Activity on Neutrophil Pro‐Inflammatory Responses
Author(s) -
Ting ChiaWei,
Hwang TsongLong,
Chen IhSheng,
Cheng MingJen,
Sung PingJyun,
Yen MingHong,
Chen JihJung
Publication year - 2014
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201300278
Subject(s) - chemistry , superoxide , elastase , derivative (finance) , garcinia , inhibitory postsynaptic potential , stereochemistry , cytochalasin , cytochalasin b , biochemistry , traditional medicine , in vitro , enzyme , cell , biology , medicine , cytoskeleton , neuroscience , financial economics , economics
A novel benzoylphloroglucinol derivative, garcimultiflorone G ( 1 ), was isolated from the fruits of Garcinia multiflora. The structure of 1 was determined through extensive 1D‐ and 2D‐NMR, and MS analyses. Garcimultiflorone G ( 1 ) showed inhibitory effects against superoxide anion (O $\rm{{_{2}^{{^\cdot} -}}}$ ) generation and elastase release by human neutrophils in response to formyl‐ L ‐methionyl‐ L ‐leucyl‐ L ‐phenylalanine/cytochalasin B (fMLP/CB), with IC 50 values of 6.97±1.56 and 11.70±1.58 μ M , respectively.