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Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection
Author(s) -
Novaković Miroslav,
Stanković Miroslava,
Vučković Ivan,
Todorović Nina,
Trifunović Snežana,
Apostolović Danijela,
Mandić Boris,
Veljić Milan,
Marin Petar,
Tešević Vele,
Vajs Vlatka,
Milosavljević Slobodan
Publication year - 2014
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201300277
Subject(s) - diarylheptanoids , chemistry , bark (sound) , micronucleus , micronucleus test , dna damage , alder , catechin , dna , stereochemistry , botany , biochemistry , antioxidant , organic chemistry , biology , toxicity , polyphenol , ecology
Nine diarylheptanoids, 1 – 9 , catechin ( 11 ), and a phenolic glucoside, 10 , were isolated from the bark of green alder ( Alnus viridis ) . Four of the isolated compounds, i.e. , 2, 5, 8, 10 , are new. The structures of 1 – 11 were determined on the basis of spectroscopic data. All isolated compounds were evaluated for their in vitro protective effects on chromosome aberrations in peripheral human lymphocytes using cytokinesis‐block micronucleus (CBMN) assay. Almost all of them exerted a pronounced effect of decreasing DNA damage of human lymphocytes, acting stronger than the known synthetic protector amifostine.