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Bioactive Tyrosine‐Derived Cytochalasins from Fungus Eutypella sp. D‐1
Author(s) -
Liu JingTang,
Hu Bo,
Gao Yun,
Zhang JianPeng,
Jiao BingHua,
Lu XiaoLing,
Liu XiaoYu
Publication year - 2014
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201300218
Subject(s) - chemistry , fungus , cytotoxicity , human breast , cancer cell lines , stereochemistry , cell culture , cytotoxic t cell , the arctic , arctic , cancer cell , biochemistry , cancer , botany , biology , in vitro , genetics , ecology , oceanography , geology
Three new cytochalasins Z 24 , Z 25 , Z 26 ( 1 – 3 , resp.) and one known compound, scoparasin B ( 4 ), were isolated from the fungus Eutypella sp. D‐1 isolated from the soil of high latitude of the Arctic. The structures of 1 – 3 were elucidated from spectroscopic data (NMR, MS). These compounds were evaluated for cytotoxic activities against several human tumor cell lines. Among them, compound 1 exhibited moderate cytotoxicity toward human breast cancer MCF‐7 cell line with IC 50 of 9.33 μ M .
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