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The Creation of Proton Hopping from a DrugReceptor Encounter
Author(s) -
Kier Lemont B.,
Hall Lowell H.
Publication year - 2013
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201300214
Subject(s) - hydronium , chemistry , effector , proton , ligand (biochemistry) , chemical physics , biophysics , axon , receptor , ion , neuroscience , physics , biochemistry , biology , organic chemistry , quantum mechanics
We extend recent modeling studies of proton hopping, used to describe the functioning of membrane channels and axon nerve conduction, to offer an explanation of the initiation of the nerve impulse at an effectorligand encounter. This encounter is proposed to create a hydronium ion in the vicinity of the effector and ligand, which leads to a continuous flow of protons, called proton hopping, through water adjacent to this encounter. This proton hopping is proposed to be the message carried from the encounter to the axon of a particular nerve system associated with that particular effectorligand system.