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Daphnane‐Type Diterpenoid Glucosides and Further Constituents of Euphorbia pilosa
Author(s) -
Zhang XuDong,
Ni Wei,
Yan Huan,
Li GenTao,
Zhong HuiMin,
Li Yan,
Liu HaiYang
Publication year - 2014
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201300154
Subject(s) - terpenoid , phytochemical , chemistry , abietane , stereochemistry , glycoside , euphorbia , euphorbiaceae , two dimensional nuclear magnetic resonance spectroscopy , traditional medicine , biochemistry , botany , biology , medicine
Phytochemical investigation of whole plants of Euphorbia pilosa led to the isolation and identification of two new daphnane‐diterpenoid glucosides, euphopilosides A and B ( 1 and 2 , resp.), and a new ent ‐abietane, euphopilolide ( 3 ), together with eight known compounds. Compounds 1 and 2 are the first daphnane‐type diterpenoid glycosides. Their structures were elucidated by a combination of 1D‐ and 2D‐NMR, and MS analyses, and acid hydrolysis. Compounds 1 – 9 were evaluated for their in vitro cytotoxicities against five human tumor cell lines, HL‐60, SMMC‐7721, A‐549, MCF‐7, and SW‐480. Compound 7 showed moderate inhibitory activity against all five cell lines.
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