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New Pterosin Sesquiterpenes and Antitubercular Constituents from Pteris ensiformis
Author(s) -
Chen JihJung,
Wang TaiChi,
Yang ChiehKai,
Liao HsiangRuei,
Sung PingJyun,
Chen IhSheng,
Cheng MingJen,
Peng ChienFang,
Chen JinnFen
Publication year - 2013
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201300072
Subject(s) - chemistry , canavalia ensiformis , sesquiterpene , in vitro , mycobacterium tuberculosis , stereochemistry , botany , traditional medicine , tuberculosis , biology , biochemistry , medicine , pathology
Two new pterosin sesquiterpenes, (2 S )‐13‐hydroxypterosin A ( 1 ) and (2 S ,3 S )‐12‐hydroxypterosin Q ( 2 ), were isolated from the whole plants of Pteris ensiformis , together with six known compounds. The structures of 1 and 2 were determined through extensive 1D/2D‐NMR and MS analyses. Compound 2 exhibited antitubercular activity ( MIC 6.25 μg/ml) against Mycobacterium tuberculosis H 37 Rv in vitro.
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