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Rare Bisindole Alkaloids from the Amazonian Tree Raputia simulans
Author(s) -
Vougogiannopoulou Konstantina,
Travasarou Aikaterini,
Fokialakis Nikolas,
Skaltsounis Alexios L.
Publication year - 2014
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201300071
Subject(s) - indole test , moiety , chemistry , phytochemical , stereochemistry , bark (sound) , rutaceae , two dimensional nuclear magnetic resonance spectroscopy , botany , biology , biochemistry , ecology
The stem bark of Raputia simulans (Rutaceae) has been reported to contain simple and dimeric indole alkaloids. Further phytochemical investigation of R. simulans stem bark resulted in the isolation of three new alkaloids. These compounds represent a relatively new category of dimeric indole alkaloids with a cyclohexene moiety in their core. Their structure elucidations were based on NMR and HR‐MS techniques, while structural aspects concerning their relative configuration were investigated using molecular mechanics calculations and NOESY experiments.