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Naphtho‐ γ ‐pyrones from Endophyte Aspergillus niger Occurring in the Liverwort Heteroscyphus tener ( Steph .) Schiffn .
Author(s) -
Li XiaoBin,
Xie Fei,
Liu ShanShan,
Li Ying,
Zhou JinChuan,
Liu YongQing,
Yuan HuiQing,
Lou HongXiang
Publication year - 2013
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201300042
Subject(s) - chemistry , aspergillus niger , endophyte , stereochemistry , fungus , aspergillus , plant use of endophytic fungi in defense , botany , biochemistry , biology
Bioactivity‐guided fractionation of the cytotoxic extract of Aspergillus niger , an endophytic fungus from the Chinese liverwort Heteroscyphus tener ( Steph .) Schiffn ., afforded five new naphtho‐ γ ‐pyrones, rubrofusarin‐6‐ O ‐ α ‐ D ‐ ribofuranoside ( 1 ), ( R )‐10‐(3‐succinimidyl)‐TMC‐256A1 ( 2 ), asperpyrone E ( 3 ), isoaurasperone A ( 4 ), and isoaurasperone F ( 5 ), as well as four known ones, dianhydroaurasperone C ( 6 ), aurasperone D ( 7 ), asperpyrone D ( 8 ), and asperpyrone A ( 9 ), together with a cytotoxic cyclic pentapeptide, malformin A 1 ( 10 ). Their structures were determined by extensive spectroscopic analysis. The absolute configurations of dimeric naphtho‐ γ ‐pyrones 3 – 9 were also determined by analysis of their respective CD spectra.