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Immobilization of 5‐Fluorouridine on Chitosan
Author(s) -
Malecki Edith,
Viere Rebecca,
Rosemeyer Helmut
Publication year - 2013
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201300025
Subject(s) - chemistry , chitosan , biopolymer , fluorophore , chitosanase , levulinic acid , silk , derivative (finance) , nuclear chemistry , biochemistry , organic chemistry , fluorescence , polymer , physics , quantum mechanics , computer science , financial economics , economics , catalysis , operating system
The 2′,3′‐ O ‐levulinic acid derivative 2b of the cancerostatic 5‐fluorouridine as well as its N(3) ‐farnesylated nucleolipid 2d were synthesized and coupled to H 2 O‐soluble chitosanes of different molecular weight and at various pH values (3.5–5.5) leading to 6 and 7 . In addition, the coumarine fluorophore ATTO‐488 N(9) ‐butanoate was bound to the biopolymer by a sequential‐coupling technique to afford 9 and 10 . Moreover, chitosan foils were prepared, to which 2b was coupled. Their degradation by chitosanase (from Streptomyces sp. N174) was studied UV‐spectrophotometrically in a Franz diffusion cell.
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