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Synthesis, Characterization, and Anti‐Amoebic Activity of N ‐(Pyrimidin‐2‐yl)benzenesulfonamide Derivatives
Author(s) -
Roouf Bhat Abdul,
Arshad Mohammad,
Ju Lee Eun,
Pokharel Smritee,
Choi Inho,
Athar Fareeda
Publication year - 2013
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201300009
Subject(s) - entamoeba histolytica , chemistry , in vitro , ic50 , metronidazole , cytotoxicity , stereochemistry , strain (injury) , nuclear chemistry , proton nmr , antimicrobial , medicinal chemistry , combinatorial chemistry , organic chemistry , biochemistry , antibiotics , microbiology and biotechnology , medicine , biology
A new series of N ‐(pyrimidin‐2‐yl)benzenesulfonamide derivatives, 3a – 3i and 4a – 4i , was synthesized from pyrimidin‐2‐amines, 2a – 2i , with the aim to explore their effects on in vitro growth of Entamoeba histolytica. The chemical structures of the compounds were elucidated by elemental analysis, FT‐IR, 1 H‐ and 13 C‐NMR, and ESI mass‐spectral data. In vitro anti‐amoebic activity was evaluated against HM1 : IMSS strain of Entamoeba histolytica. The IC 50 values were calculated by using the double dilution method. The results were compared with the IC 50 value of the standard drug ‘metronidazole’. The selected compounds were tested for their cytotoxic activities by cell‐viability assay using H9C2 cardiac myoblasts cell line, and the results indicated that all the compounds displayed remarkable >80% viabilities to a concentration of 100 μg/ml.