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Norlathyrane Diterpenes from the Root of Euphorbia kansuensis
Author(s) -
Zhang BeiBei,
Jiang Qian,
Liao ZhiXin,
Liu Chao,
Liu ShiJun,
Ji LanJu,
Sun HongFa
Publication year - 2013
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201300004
Subject(s) - phytochemical , euphorbia , chemistry , hela , euphorbiaceae , stereochemistry , traditional medicine , botany , biology , in vitro , biochemistry , medicine
Abstract Phytochemical investigation of the EtOH extract obtained from the root of the Euphorbia kansuensis Proch . grown in China resulted in the isolation of two novel norlathyrane diterpenes, named ekanpenoids A and B ( 1 and 2 , resp.). Their structures were established by extensive 1D‐ and 2D‐NMR spectroscopy, as well as other spectra. The isolated diterpenes exhibited potent cytotoxic activities against the HeLa and Hep‐G2 cell lines with the IC 50 values ranging from 3.6 to 9.7 μg/ml.