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Heat Shock Factor 1 Inducers from the Bark of Eucommia ulmoides as Cytoprotective Agents
Author(s) -
Nam JooWon,
Kim SeoYoung,
Yoon Taesook,
Lee Yoo Jin,
Kil YunSeo,
Lee YunSil,
Seo EunKyoung
Publication year - 2013
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201200401
Subject(s) - eucommia ulmoides , chemistry , inducer , hsf1 , pinoresinol , traditional medicine , lignan , hsp70 , pharmacology , biochemistry , heat shock protein , stereochemistry , traditional chinese medicine , biology , gene , medicine , alternative medicine , pathology
The barks of Eucommia ulmoides (Eucommiae Cortex, Eucommiaceae) have been used as a traditional medicine in Korea, Japan, and China to treat hypertension, reinforce the muscles and bones, and recover the damaged liver and kidney functions. Among these traditional uses, to establish the recovery effects on the damaged organs on the basis of phytochemistry, the barks of E. ulmoides have been investigated to afford three known phenolic compounds, coniferaldehyde glucoside ( 1 ), bartsioside ( 2 ), and feretoside ( 3 ), which were found in the family Eucommiaceae for the first time. The compounds 1 – 3 were evaluated for their inducible activities on the heat shock factor 1 (HSF1), and heat shock proteins (HSPs) 27 and 70, along with four compounds, geniposide ( 4 ), geniposidic acid ( 5 ), pinoresinol diglucoside ( 6 ), and liriodendrin ( 7 ), which were previously reported from E. ulmoides. Compounds 1 – 7 increased expression of HSF1 by a factor of 1.214, 1.144, 1.153, 1.114, 1.159, 1.041, and 1.167 at 3 μ M , respectively. Coniferaldehyde glucoside ( 1 ) showed the most effective increase of HSF1 and induced successive expressions of HSP27 and HSP70 in a dose‐dependent manner without cellular cytotoxicity, suggesting a possible application as a HSP inducer to act as cytoprotective agent.