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Imidazopyridine‐Based Inhibitors of Glycogen Synthase Kinase 3: Synthesis and Evaluation of Amide Isostere Replacements of the Carboxamide Scaffold
Author(s) -
Yngve Ulrika,
Söderman Peter,
Svensson Mats,
Rosqvist Susanne,
Arvidsson Per I.
Publication year - 2012
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201200308
Subject(s) - chemistry , bioisostere , isostere , imidazopyridine , amide , gsk 3 , carboxamide , thiazole , glycogen synthase , combinatorial chemistry , sulfonamide , kinase , enzyme , biochemistry , stereochemistry , chemical synthesis , in vitro
In this study, we explored the effect of bioisostere replacement in a series of glycogen synthase kinase 3 (GSK3) inhibitors based on the imidazopyridine core. The synthesis and biological evaluation of a number of novel sulfonamide, 1,2,4‐oxadiazole, and thiazole derivates as amide bioisosteres, as well as a computational rationalization of the obtained results are reported.