Imidazopyridine‐Based Inhibitors of Glycogen Synthase Kinase 3: Synthesis and Evaluation of Amide Isostere Replacements of the Carboxamide Scaffold | Zendy

Yngve Ulrika | Zendy; Söderman Peter | Zendy; Svensson Mats | Zendy; Rosqvist Susanne | Zendy; Arvidsson Per I. | Zendy

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Imidazopyridine‐Based Inhibitors of Glycogen Synthase Kinase 3: Synthesis and Evaluation of Amide Isostere Replacements of the Carboxamide Scaffold

Author(s) -

Yngve Ulrika,

Söderman Peter,

Svensson Mats,

Rosqvist Susanne,

Arvidsson Per I.

Publication year - 2012

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.201200308

Subject(s) - chemistry , bioisostere , isostere , imidazopyridine , amide , gsk 3 , carboxamide , thiazole , glycogen synthase , combinatorial chemistry , sulfonamide , kinase , enzyme , biochemistry , stereochemistry , chemical synthesis , in vitro

In this study, we explored the effect of bioisostere replacement in a series of glycogen synthase kinase 3 (GSK3) inhibitors based on the imidazopyridine core. The synthesis and biological evaluation of a number of novel sulfonamide, 1,2,4‐oxadiazole, and thiazole derivates as amide bioisosteres, as well as a computational rationalization of the obtained results are reported.

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