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Synthesis, Biological Evaluation, and Live Cell Imaging of Novel Fluorescent Duocarmycin Analogs
Author(s) -
Tietze Lutz F.,
Behrendt Frank,
Pestel Galina F.,
Schuberth Ingrid,
Mitkovski Mišo
Publication year - 2012
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201200289
Subject(s) - chemistry , fluorescence , confocal , confocal microscopy , live cell imaging , confocal laser scanning microscopy , biophysics , cell , microbiology and biotechnology , biochemistry , biology , optics , physics
For a better understanding of the mode of action of duocarmycin and its analogs, the novel fluorescent duocarmycin derivatives 13 – 15 and 17b – 19b were synthesized, and their bioactivity as well as their cellular uptake investigated using confocal laser scanning microscopy (CLSM) in live‐cell imaging experiments.