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Diterpenoids from Acanthopanax brachypus Harms
Author(s) -
Hu HaoBin,
Zheng XuDong,
Hu HuaiSheng,
Wu Yun
Publication year - 2013
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201200262
Subject(s) - chemistry , cytotoxicity , stereochemistry , bark (sound) , traditional medicine , biochemistry , in vitro , biology , medicine , ecology
Four diterpenoids, including two new ones, namely noracanthopanin A ( 1 ) and acanthopanolide B ( 2 ), and two known ones, ent ‐pimara‐9(11),15‐dien‐19‐oic acid ( 3 ) and ent ‐kaur‐16‐en‐19‐oic acid ( 4 ), were isolated from the stem bark of Acanthopanax brachypus Harms . Their structures were elucidated by physicochemical and spectroscopic analyses. Compound 1 and 2 exhibited moderate cytotoxicities against HO‐8910 cells with IC 50 values of 65.21±0.23 and 31.43±1.01 μg/ml, respectively, and 2 showed selective weak cytotoxicity against SMMC‐7721 cells ( IC 50 89.67±2.54 μg/ml).
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