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Four Flavanocoumarins from the Leaves of Litsea coreana Levl.
Author(s) -
Tang WenJian,
Zhang YiLong,
Xiao QingPin,
Huang Cheng,
Jin Yong,
Li Jun
Publication year - 2013
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201200236
Subject(s) - chemistry , traditional medicine , tumor necrosis factor alpha , biology , immunology , medicine
Two new flavanocoumarins, 1 and 2 , together with phyllocoumarin ( 3 ) and epiphyllocoumarin ( 4 ), were isolated from the leaves of Litsea coreana Levl. in Anhui Province, China. The structures of 1 – 4 were elucidated by spectroscopic methods. Biological tests revealed that 1 – 4 exhibited moderate anti‐inflammatory activities through inhibition of TNF‐ α and IL‐1 production in primary mouse peritoneal macrophages activated with lipopolysaccharides (LPS).