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Cytotoxic ent ‐Kaurane Diterpenoids from Isodon nervosus
Author(s) -
Gao YouHeng,
Wei ZhiXiong,
Cheng Yi,
Wang TengHua,
Ni Lin,
Zhou XiaoHong,
Zhang LiYuan
Publication year - 2013
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201200201
Subject(s) - chemistry , cytotoxicity , stereochemistry , two dimensional nuclear magnetic resonance spectroscopy , cytotoxic t cell , diterpene , biochemistry , in vitro
Four new ent ‐kaurane diterpenoids, rabdonervosins G–J ( 1 – 4 , resp.), were isolated from the leaves and stems of Isodon nervosus. Their structures were elucidated by extensive spectroscopic analyses, including 1D‐, 2D‐NMR and HR mass spectra. Compound 2 showed potent cytotoxicity against the HepG2 and PC‐9/ZD cell lines with IC 50 values of 2.36 and 6.07 μ M , respectively, and compound 3 exhibited cytotoxicity against the HepG2 and CNE2 cell lines with IC 50 values of 8.64 and 9.77 μ M , respectively.
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