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Synthesis, Physicochemical Properties, and in vitro Antibacterial Screening of Palladium(II) Complexes Derived from Thiosemicarbazone
Author(s) -
Azam Mohammad,
Warad Ismail,
AlResayes Saud I.,
Siddiqui M. Rafiq,
Oves M.
Publication year - 2013
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201200128
Subject(s) - semicarbazone , chemistry , bacillus subtilis , antibacterial activity , in vitro , escherichia coli , ligand (biochemistry) , palladium , pseudomonas aeruginosa , staphylococcus aureus , bacteria , nuclear chemistry , copper , stereochemistry , organic chemistry , biochemistry , receptor , catalysis , biology , genetics , gene
Abstract A new series of Pd II complexes derived from thiosemicarbazone has been synthesized. The synthesized Pd II complexes have been characterized on the basis of elemental analyses, FT‐IR, 1 H‐ and 13 C‐NMR, UV/VIS, and thermal studies. A square‐planar geometry has been assigned around Pd II ions on the basis of results obtained from UV/VIS studies. The thiosemicarbazone ligand and its Pd II complexes have been screened against Gram ‐positive ( Bacillus subtilis and Staphylococcus aureus ) and Gram ‐negative ( Escherichia coli and Pseudomonas aeruginosa ) bacteria in vitro as growth‐inhibiting agents, and the results revealed significant antibacterial activities.