Premium
Alkaloids from Cephalotaxus lanceolata and Their Cytotoxicities
Author(s) -
He YiRen,
Shen YunHeng,
Li Bo,
Li Bo,
Lu Lu,
Tian JunMian,
Zhang WeiDong
Publication year - 2013
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201200105
Subject(s) - chemistry , phytochemical , stereochemistry , two dimensional nuclear magnetic resonance spectroscopy , a549 cell , traditional medicine , cell , biochemistry , medicine
A phytochemical investigation of the branches and leaves of Cephalotaxus lanceolata resulted in the isolation of three new cephalotaxus alkaloids, cephalancetines A, B, and D ( 1, 2 , and 4 , resp.), together with ten known alkaloids, 3 and 5 – 13 . The structures of the alkaloids were elucidated on the basis of spectroscopic analyses, including 1D‐ and 2D‐NMR, and HR‐ESI‐MS, and single‐crystal X‐ray diffraction. All isolated compounds were tested for their cytotoxicities against four human tumor cell lines, A549, HCT116, SK‐BR‐3, and HepG2. Compounds 12 and 13 showed remarkable activities against A549, HCT116, and HepG2 cell lines.