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Triterpene Glucosides from the Leaves of Aralia elata and Their Cytotoxic Activities
Author(s) -
Kuang HaiXue,
Wang ZhiBin,
Wang QiuHong,
Yang BingYou,
Xiao HongBin,
Okada Yoshihito,
Okuyama Tohru
Publication year - 2013
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201200087
Subject(s) - chemistry , triterpene , stereochemistry , dept , hederagenin , two dimensional nuclear magnetic resonance spectroscopy , cytotoxicity , heteronuclear single quantum coherence spectroscopy , traditional medicine , cytotoxic t cell , terpene , biochemistry , in vitro , medicine , alternative medicine , pathology
Three new triterpene glucosides, named congmuyenosides C–E ( 1 – 3 , resp.), along with four known ones, were isolated from an EtOH extract of Aralia elata ( Miq .) Seem . leaves. The structures of the new compounds were identified as 3‐ O ‐{ β ‐ D ‐glucopyranosyl‐(1→3)‐ β ‐ D ‐glucopyranosyl‐(1→3)‐[ β ‐ D ‐glucopyranosyl‐(1→2)]‐ β ‐ D ‐glucopyranosyl}caulophyllogenin ( 1 ), 3‐ O ‐{ β ‐ D ‐glucopyranosyl‐(1→3)‐ β ‐ D ‐glucopyranosyl‐(1→3)‐[ β ‐ D ‐glucopyranosyl‐(1→2)]‐ β ‐ D ‐glucopyranosyl}hederagenin 28‐ O ‐ β ‐ D ‐glucopyranosyl ester ( 2 ), 3‐ O ‐{ β ‐ D ‐glucopyranosyl‐(1→3)‐ β ‐ D ‐glucopyranosyl‐(1→3)‐[ β ‐ D ‐glucopyranosyl‐(1→2)]‐ β ‐ D ‐glucopyranosyl}echinocystic acid 28‐ O ‐ β ‐ D ‐glucopyranosyl ester ( 3 ) on the basis of spectral analyses, including MS, 1 H‐NMR, 13 C‐NMR, DEPT, HSQC, HMBC, NOESY, and HSQC‐TOCSY experiments. All isolates obtained were evaluated for their cytotoxic activities against three human tumor cell lines (HepG2, SKOV3, and A549). Compound 3 showed significant cytotoxicity against A549 cell line ( IC 50 9.9±1.5 μ M ).