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Pierisformotoxins A – D, Polyesterified Grayanane Diterpenoids from Pieris formosa and Their cAMP‐Decreasing Activities
Author(s) -
Wang WeiGuang,
Wu ZhaoYuan,
Chen Rui,
Li HaiZhou,
Li HongMei,
Li YuanDan,
Li RongTao,
Luo HuaiRong
Publication year - 2013
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201200046
Subject(s) - chemistry , stereochemistry , ring (chemistry) , lactone , cleavage (geology) , biology , organic chemistry , paleontology , fracture (geology)
Four highly acylated diterpenoids, designated as pierisformotoxins A–D ( 1 – 4 , resp.), along with 26 known compounds, were isolated from the flowers of Pieris formosa. Among them, pierisformotoxins A and B ( 1 and 2 , resp.) were new highly acylated grayanane diterpenoids, of which the five‐membered ring A has undergone an oxidative cleavage between C(3) and C(4), followed by lactonization, to give rise to a five‐membered lactone ring between C(3) and C(5), differing from the previously reported grayanane diterpenoids with a 5/7/6/5 ring system. Results of the cAMP‐regulation‐activity assay showed that pierisformotoxin C ( 3 ) at 10 μ M (inhibitory ratio ( IR ): 10.1%) or 2 μ M (9.8%), and pierisformotoxin B ( 2 ) at 50 μ M (13.9%) significantly decreased the cAMP level in N1E‐115 neuroblastoma cells ( p <0.05).