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Chemical Composition and Antimicrobial Activity of Essential Oils from Chromolaena laevigata during Flowering and Fruiting Stages
Author(s) -
Murakami Cynthia,
Lago João H. G.,
Perazzo Fábio F.,
Ferreira Karen S.,
Lima Marcos E. L.,
Moreno Paulo R. H.,
Young Maria C. M.
Publication year - 2013
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201200025
Subject(s) - antimicrobial , candida albicans , sesquiterpene , staphylococcus aureus , essential oil , chemotype , chemistry , minimum inhibitory concentration , corpus albicans , botany , food science , biology , microbiology and biotechnology , bacteria , genetics
The chemical compositions and antimicrobial activities of essential oils from the leaves, stems, capitula, and cypselas of Chromolaena laevigata were evaluated at two different phenological stages, flowering and fruiting. Thirty‐eight compounds were identified in the crude oils by GC/MS. The sesquiterpene laevigatin was the major constituent of the leaf, capitulum, and cypsela oils, while the sesquiterpene spathulenol was the main component in the stem oils. The antimicrobial activities of the oils were evaluated against Candida albicans, Staphylococcus aureus, Pseudomonas aeruginosa , and Escherichia coli. Stem oil obtained from Chromolaena laevigata during the fruiting stage generally showed the highest activity with minimum inhibitory concentration ( MIC ) values of 62.5 μg/ml against Candida albicans and S. aureus , and 500 μg/ml against P. aeruginosa and E. coli. Pure laevigatin exhibited MIC values of 500 and 125 μg/ml against C. albicans and S. aureus , respectively, indicating that this constituent could be responsible, at least in part, for the antimicrobial activities detected in the crude oils. More studies concerning the biological activities of isolated derivatives are required to improve our knowledge of the antimicrobial potential of volatile compounds present in native plants.