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Coordination of Thiosemicarbazones and Bis(thiosemicarbazones) to Bismuth(III) as a Strategy for the Design of Metal‐Based Antibacterial Agents
Author(s) -
Lessa Josane A.,
Reis Débora C.,
Da Silva Jeferson G.,
Paradizzi Lúcia T.,
da Silva Nayane F.,
de Fátima A. Carvalho Mariany,
Siqueira Sarah A.,
Beraldo Heloisa
Publication year - 2012
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201100447
Subject(s) - chemistry , semicarbazone , antibacterial activity , enterococcus faecalis , pseudomonas aeruginosa , staphylococcus epidermidis , medicinal chemistry , pyridine , staphylococcus aureus , bismuth , stereochemistry , nuclear chemistry , bacteria , organic chemistry , escherichia coli , biochemistry , genetics , gene , biology
Complexes [Bi(2Fo4Ph)Cl 2 ] ( 1 ), [Bi(2Ac4Ph)Cl 2 ] ( 2 ), [Bi(2Bz4Ph)Cl 2 ] ( 3 ), [Bi(H 2 Gy3DH)Cl 3 ] ( 4 ), [Bi(H 2 Gy4Et)(OH) 2 Cl] ( 5 ), and [Bi(H 2 Gy4Ph)Cl 3 ] ( 6 ) were prepared with pyridine‐2‐carbaldehyde 4‐phenylthiosemicarbazone (H2Fo4Ph), 1‐(pyridin‐2‐yl)ethanone 4‐phenylthiosemicarbazone (H2Ac4Ph), phenyl(pyridin‐2‐yl)methanone 4‐phenylthiosemicarbazone (H2Bz4Ph), as well as with glyoxaldehyde bis(thiosemicarbazone) (H 2 Gy4DH) and its 4‐Et (H 2 Gy4Et) and 4‐Ph (H 2 Gy4Ph) derivatives. The complexes exhibited antibacterial activities against Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis , and Pseudomonas aeruginosa. Coordination to Bi III proved to be an effective strategy to increase the antibacterial activity of the thiosemicarbazones and bis(thiosemicarbazones).