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Group‐10 Metal Complexes of Biological Molecules and Related Ligands: Structural and Functional Properties
Author(s) -
Shimazaki Yuichi,
Yamauchi Osamu
Publication year - 2012
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201100446
Subject(s) - chemistry , molecule , catalysis , metal , combinatorial chemistry , functional group , small molecule , biological activity , biomolecule , stereochemistry , organic chemistry , biochemistry , in vitro , polymer
The complexes of group‐10 metals, Ni, Pd, and Pt, with biological molecules and related ligands have been attracting increasing attention in recent years due to their reactivities and functions, such as catalysts and drugs, and their biological relevance. The well‐defined structures and kinetic inertness especially of Pt complexes have been used as the sites for weak interactions with other molecules. The Ni complexes have been reported as models not only for Ni enzymes but also for other metalloenzyme active sites for deeper understanding of the reactivities such as oxygen activations and detailed electronic structures. Pd Complexes are widely known for their catalytic activities in conversions of various organic molecules including useful biological molecules, such as SuzukiMiyaura cross‐coupling, while Pt complexes have been intensively studied for their antitumor activities. We focus in this review on our recent results on weak interactions and reactivities of the group‐10 metal complexes with biological molecules and related compounds, and discuss their structural features and some new properties pointing to functional possibilities.