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A Synthetic Pathway for an Unsymmetrical N 5 O 2 Heptadentate Ligand and Its Heterodinuclear Iron(III)Zinc(II) Complex: A Biomimetic Model for the Purple Acid Phosphatases
Author(s) -
Xavier Fernando R.,
Bortoluzzi Adailton J.,
Neves Ademir
Publication year - 2012
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201100436
Subject(s) - chemistry , bioinorganic chemistry , potentiometric titration , ligand (biochemistry) , stereochemistry , zinc , circular dichroism , reactivity (psychology) , crystal structure , inorganic chemistry , medicinal chemistry , crystallography , organic chemistry , biochemistry , medicine , ion , receptor , alternative medicine , pathology
One major field of interest in bioinorganic chemistry is the design and synthesis of inorganic compounds with low molecular mass, showing structural, spectroscopic, and reactivity properties that mimic enzymes, such as purple acid phosphatases (PAPs). In this study, the unsymmetrical heptadentate ligand 2‐[(4,7‐diisopropyl‐1,4,7‐triazacyclonon‐1‐yl)methyl]‐6‐{[(2‐hydroxybenzyl)(pyridin‐2‐ylmethyl)‐amino]methyl}‐4‐methylphenol ( H 2 L ) and its first mixed‐valence complex [Fe III Zn II (L)( μ ‐OAc) 2 ]ClO 4 ( 1 ) were synthesized. Physical and chemical measurements (crystal structure, conductometry, IR and UV/VIS spectroscopy, and electrochemistry) were performed for 1 , and these properties are compared with those presented by the kbPAPs active sites. Potentiometric titration studies of 1 have confirmed its acid/base properties that are crucial for the understanding of the phosphodiester and DNA catalytic cleavage in future studies.