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Cytotoxic Tetraprenylated Alkaloids from the South China Sea Gorgonian Euplexaura robusta
Author(s) -
Zhang JinRong,
Li PingLin,
Tang XuLi,
Qi Xin,
Li GuoQiang
Publication year - 2012
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201100374
Subject(s) - gorgonian , hela , stereochemistry , chemistry , two dimensional nuclear magnetic resonance spectroscopy , biology , cell , biochemistry , ecology , coral
Nine achiral tetraprenylated alkaloids, including three new compounds, named malonganenones I–K ( 1 – 3 , resp.), together with six known analogs, 4 – 9 , were isolated from the gorgonian Euplexaura robusta collected from Weizhou Island of Guangxi Province, China. The structures of compounds 1 – 3 were elucidated by extensive spectral analyses, especially of their 1D‐ and 2D‐NMR data. Compounds 1, 4, 6 , and 7 showed moderate cytotoxicities against K562 and HeLa tumor cell lines with IC 50 values ranging from 0.35 to 10.82 μ M . Compound 6 also showed moderate inhibitory activity against c‐Met kinase at a concentration of 10 μ M .