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Isolation and Characterization of Two Novel Antibacterial Cyclic Hexapeptides from Streptomyces alboflavus 313
Author(s) -
Ji Zhiqin,
Qiao Gang,
Wei Shaopeng,
Fan Lixia,
Wu Wenjun
Publication year - 2012
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201100364
Subject(s) - bacillus cereus , bacillus subtilis , staphylococcus aureus , chemistry , bacteria , antibacterial activity , microbiology and biotechnology , streptomyces , cereus , ampicillin , minimum inhibitory concentration , isolation (microbiology) , gram positive bacteria , pathogenic bacteria , antimicrobial , biology , antibiotics , biochemistry , genetics
Two novel cyclic hexapeptides, designated NW‐G08 ( 1 ) and NW‐G09 ( 2 ), were isolated from the fermentation broth of Streptomyces alboflavus 313. Their structures were elucidated on the basis of extensive spectroscopic analysis, MS experiments, and chemical analysis. Their antibacterial activities against several strains of bacteria were evaluated by micro‐broth dilution method. NW‐G08 ( 1 ) and NW‐G09 ( 2 ) were highly antibacterial against Gram ‐positive but not active against Gram ‐negative bactaria. The minimum inhibitory concentrations ( MIC s) of 1 against Bacillus cereus, Bacillus subtilis , and Staphylococcus aureus were 6.25, 6.25, and 1.56 μg/ml, respectively. It is worth noting that 1 and 2 exhibited much higher activities against methicillin‐resistant Staphylococcus aureus (MRSA) than ampicillin, which implies that they might be potential candidates for the development of novel drugs against resistant pathogenic bacteria.