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Novel Zierane‐ and Guaiane‐Type Sesquiterpenes from the Root of Melicope denhamii
Author(s) -
Nakashima Kenichi,
Oyama Masayoshi,
Ito Tetsuro,
Witono Joko Ridho,
Darnaedi Dedy,
Tanaka Toshiyuki,
Murata Jin,
Iinuma Munekazu
Publication year - 2012
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201100345
Subject(s) - chemistry , stereochemistry , cytotoxicity , terpene , traditional medicine , biochemistry , in vitro , medicine
Two novel zierane‐type sesquiterpenes, named melicodenones A and B ( 1 and 2 , resp.), and three new guaiane‐type sesquiterpenes, named melicodenones C–E ( 3 – 5 ), were isolated from the root of Melicope denhamii ( Seem. ) T. G. Hartley together with zierone ( 6 ). Their structures were established by extensive NMR‐spectroscopic analyses. Compounds 1 – 6 were tested for cytotoxicity using human colon cancer DLD‐1 cells, and melicodenone A ( 1 ) was found to exhibit moderate activity.