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Antioxidation and DNA‐Binding Properties of Binuclear Lanthanide(III) Complexes with a Schiff Base Ligand Derived from 8‐Hydroxyquinoline‐7‐carboxaldehyde and Benzoylhydrazine
Author(s) -
Liu Yongchun,
Zhang Kejun,
Wu Yun,
Zhao Junying,
Liu Jianning
Publication year - 2012
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201100322
Subject(s) - chemistry , ligand (biochemistry) , schiff base , dibasic acid , intercalation (chemistry) , lanthanide , 8 hydroxyquinoline , stereochemistry , monomer , medicinal chemistry , dna , crystallography , polymer chemistry , inorganic chemistry , ion , organic chemistry , receptor , biochemistry , polymer
8‐Hydroxyquinoline‐7‐carboxaldehyde (8‐HQ‐7‐CA), Schiff ‐base ligand 8‐hydroxyquinoline‐7‐carboxaldehyde benzoylhydrazone, and binuclear complexes [LnL(NO 3 )(H 2 O) 2 ] 2 were prepared from the ligand and equivalent molar amounts of Ln(NO 3 )⋅6 H 2 O (Ln=La 3+ , Nd 3+ , Sm 3+ , Eu 3+ , Gd 3+ , Dy 3+ , Ho 3+ , Er 3+ , Yb 3+ , resp.). Ligand acts as dibasic tetradentates, binding to Ln III through the phenolate O‐atom, N‐atom of quinolinato unit, and CN and OCN groups of the benzoylhydrazine side chain. Dimerization of this monomeric unit occurs through the phenolate O‐atoms leading to a central four‐membered (LnO) 2 ring. Ligand and all of the Ln III complexes can strongly bind to CT‐DNA through intercalation with the binding constants at 10 5 –10 6 M −1 . Moreover, ligand and all of the Ln III complexes have strong abilities of scavenging effects for hydroxyl (HO . ) radicals. Both the antioxidation and DNA‐binding properties of Ln III complexes are much better than that of ligand.