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New Antiplasmodial Bromotyrosine Derivatives from Suberea ianthelliformis Lendenfeld , 1888
Author(s) -
Mani Luke,
Jullian Valerie,
Mourkazel Beatrice,
Valentin Alexis,
Dubois Joëlle,
Cresteil Thierry,
Folcher Eric,
Hooper John N. A.,
Erpenbeck Dirk,
Aalbersberg William,
Debitus Cécile
Publication year - 2012
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201100309
Subject(s) - chemistry , plasmodium falciparum , stereochemistry , derivative (finance) , inhibitory postsynaptic potential , formamide , organic chemistry , malaria , biology , neuroscience , economics , financial economics , immunology
Abstract Four samples of Suberea ianthelliformis were investigated and furnished five new and 13 known brominated tyrosine‐derived compounds. Two of the new compounds were identified as araplysillin N20‐formamide and its N‐ oxide derivative. Three other new compounds, araplysillins IV, V, and VI, were isolated and identified as analogs of araplysillin II. Most of these compounds exhibit moderate inhibitory activities against chloroquine‐resistant and ‐sensitive strains of Plasmodium falciparum , and were investigated for their PFTase inhibitory properties. The chemical content of the investigated sponges is correlated with their molecular phylogeny.