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Chemical Constituents of Saniculiphyllum guangxiense
Author(s) -
Geng ChangAn,
Huang XiaoYan,
Lei LiGong,
Zhang XueMei,
Chen JiJun
Publication year - 2012
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201100270
Subject(s) - chemistry , chemical constituents , environmental chemistry , chromatography
The first phytochemical investigation on Saniculiphyllum guangxiense resulted in the isolation of two new triterpenoids, 16 β ‐hydroxybryodulcosigenin ( 3 ) and 3 α ‐ O ‐feruloylolean‐12‐en‐27‐oic acid ( 6 ), together with six known compounds, menisdaurin ( 1 ), purshianin ( 2 ), oleanolic acid ( 4 ), 3 β ‐hydroxyolean‐12‐en‐27‐oic acid ( 5 ), β ‐sitosterol ( 7 ), and daucosterol ( 8 ), which were characterized by extensive spectroscopic analyses and in one case by X‐ray diffraction. According to this primary investigation, S. guangxiense is rich in nitrile glucosides and triterpenoids, of which menisdaurin ( 1 ; 0.06%) and purshianin ( 2 ; 0.015%) are the main constituents. Compounds 1 – 6 were assayed for their anti‐hepatitis B virus (HBV) activities against the secretion of HBsAg and HBeAg, as well as HBV DNA replication on Hep G 2.2.15 cell line in vitro. The most active compound, menisdaurin ( 1 ), inhibits HBV DNA replication with an IC 50 value of 0.32 m M ( SI >11.97).