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Jiangxienone, a New Compound with Potent Cytotoxicity against Tumor Cells from Traditional Chinese Medicinal Mushroom Cordyceps jiangxiensis
Author(s) -
Xiao JianHui,
Sun ZhongHua,
Pan WeiDong,
Lü YuHong,
Chen DaiXiong,
Zhong JianJiang
Publication year - 2012
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201100244
Subject(s) - cytotoxicity , cisplatin , cordyceps , chemistry , mushroom , cytotoxic t cell , cell culture , adenocarcinoma , traditional medicine , pharmacology , cancer , chemotherapy , biochemistry , in vitro , biology , medicine , food science , genetics
A new compound, named jiangxienone, has been isolated from a culture of the traditional Chinese medicinal mushroom Cordyceps jiangxiensis , and its chemical structure was established on the basis of spectroscopic and chemical techniques. Jiangxienone showed potent cytotoxic effects against human gastric adenocarcinoma SGC‐7901 cell and human lung carcinoma A549 cell with IC 50 values ranging from 1.38 to 2.93 μ M , i.e. , with at least approximately six‐fold stronger cytotoxicity than cisplatin, a first‐line chemotherapy drug for cancer patients.