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Isolation and Neuroprotective Activities of Acylated Iridoids from Valeriana jatamansi
Author(s) -
Xu Jing,
Guo Yuanqiang,
Xie Chunfeng,
Jin DaQing,
Gao Jie,
Gui Liping
Publication year - 2012
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201100238
Subject(s) - neuroprotection , chemistry , epimer , pharmacology , stereochemistry , dopaminergic , traditional medicine , neuroscience , dopamine , biology , medicine
Three new iridoids, jatairidoids A–C ( 1 – 3 , resp.), have been isolated from the roots of Valeriana jatamansi ( V. wallichii ). Their structures were elucidated by spectroscopic methods (IR, ESI‐MS, HR‐ESI‐MS, 1D‐ and 2D‐NMR). Compounds 1 and 2 are C(3)‐ epimers. The three compounds were evaluated for their neuroprotective effects against MPP + ‐induced neuronal cell death in human dopaminergic neuroblastoma SH‐SY5Y cells. All the isolates exhibited moderate neuroprotective effects.