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Sesquiterpenes and Cyclopeptides from the Endophytic Fungus Trichoderma asperellum Samuels, Lieckf. & Nirenberg
Author(s) -
Ding Gang,
Chen Amanda Juan,
Lan Jin,
Zhang Hongwu,
Chen Xiangdong,
Liu Xingzhong,
Zou Zhongmei
Publication year - 2012
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201100185
Subject(s) - panax notoginseng , chemistry , absolute configuration , two dimensional nuclear magnetic resonance spectroscopy , enterococcus faecium , stereochemistry , staphylococcus aureus , antibacterial activity , fungus , botany , bacteria , antibiotics , biology , biochemistry , medicine , alternative medicine , pathology , genetics
Trichodones A–C ( 1 – 3 , resp.), three new sesquiterpenes, together with the two known cyclopeptides PF1022F and halobacillin ( 4 and 5 , resp.), have been isolated from the crude extract of the endophytic fungus Trichoderma asperellum Samuels, Lieckf. & Nirenberg residing in the traditional Chinese medicinal plant Panax notoginseng (Burkill ) F.H.Chen . The structures and configurations of compounds 1 – 3 were determined by NMR spectroscopy and mass spectrometry. The relative configuration for 1 was determined by analysis of its pertinent coupling constants and NOESY correlations, whereas the absolute configuration of 1 was established by CD spectroscopy. Compounds 4 and 5 displayed antibacterial activities against Enterococcus faecium (CGMCC 1.2025) with IC 50 values of 7.30 and 5.24 μ m, and against Staphylococcus aureus COL (CGMCC 1.2465) with IC 50 values of 19.02 and 14.00 μ M , respectively.
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