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Historical Variation of Structural Novelty in a Natural Product Library
Author(s) -
Kong DeXin,
Guo MingYue,
Xiao ZhiHong,
Chen LingLing,
Zhang HongYu
Publication year - 2011
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201100156
Subject(s) - novelty , natural product , natural (archaeology) , redundancy (engineering) , product (mathematics) , computer science , information retrieval , chemistry , mathematics , biology , philosophy , stereochemistry , paleontology , geometry , theology , operating system
To evaluate the potential of natural products as novel structure suppliers, a historical analysis was performed on the structural novelty of a natural product library, viz. , the Chapman & Hall / CRC Dictionary of Natural Products. The results show that although the unexplored natural product universe is still ample, it is more and more difficult to find novel agents from nature, with the discovery probability of novel structures and scaffolds being lower than 50% in the near future, which mainly results from the intrinsic redundancy of natural products and, thus, is unlikely to be reversed merely through technical progresses.