Two New Norlignans and a New Lignanamide from  Peperomia tetraphylla | Zendy

Li YunZhi | Zendy; Tong AiPing | Zendy; Huang Jing | Zendy

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Two New Norlignans and a New Lignanamide from Peperomia tetraphylla

Author(s) -

Li YunZhi,

Tong AiPing,

Huang Jing

Publication year - 2012

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.201100138

Subject(s) - hela , chemistry , cyclobutane , stereochemistry , cytotoxicity , ether , cancer cell lines , cytotoxic t cell , cancer cell , organic chemistry , cell , biochemistry , in vitro , cancer , biology , ring (chemistry) , genetics

Two new cyclobutane‐type norlignans, methyl rel ‐(1 R ,2 S ,3 S )‐2‐(7‐methoxy‐1,3‐benzodioxol‐5‐yl)‐3‐(2,4,5‐trimethoxyphenyl)cyclobutanecarboxylate ( 1 ), and methyl rel ‐(1 R ,2 R ,3 S )‐2‐(7‐methoxy‐1,3‐benzodioxol‐5‐yl)‐3‐(2,4,5‐trimethoxyphenyl)cyclobutanecarboxylate ( 2 ), and a new lignanamide, 3‐hydroxy‐ N ‐[2‐(4‐hydroxyphenyl)ethyl]‐ α ‐[4‐(2‐{ N ‐[2‐(4‐hydroxyphenyl)ethyl]carbamoyl}ethenyl)‐3‐methoxyphenoxy]‐4‐methoxycinnamamide 4,8″‐ether ( 3 ), along with five known amides, 4 – 8 , were obtained from the whole plant of Peperomia tetraphylla. Their structures were elucidated mainly by the analysis of NMR and MS data. The new compounds 1 – 3 and the known compound 4 were tested for their cytotoxic activities against the HepG2 (human hepatocarcinoma), A549 (human lung cancer), and HeLa (human cervical cancer) cell lines. Compound 4 showed significant cytotoxicity against HepG2 cell lines with an IC 50 value of 9.4±1.0 μ M .

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