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Anticandidal Activity of the Essential Oil of Nepeta transcaucasica Grossh.
Author(s) -
İşcan Gökalp,
Köse Y. Bülent,
Demirci Betül,
Can Başer K. Hüsnü
Publication year - 2011
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201100091
Subject(s) - lamiaceae , nepeta , chemistry , broth microdilution , essential oil , germacrene d , minimum inhibitory concentration , candida glabrata , food science , traditional medicine , antimicrobial , botany , antifungal , microbiology and biotechnology , biology , organic chemistry , medicine
Hydrodistallation of the aerial parts of Nepeta transcaucasica Grossh . (Lamiaceae), collected in Ağrı, Doğubayazıt Province, afforded an essential oil that was characterized by GC and GC/MS analyses. Twenty‐seven compounds, representing 97.69% of the total oil composition, were identified, and 4a α ,7 α ,7a β ‐nepetalactone ( 1 ; 39%), 4a α ,7 α ,7a α ‐nepetalactone ( 2 ; 28%), and germacrene D ( 3 ; 15%) constituted the major components. The anticandidal effects of the oil were evaluated against seven Candida strains by using the broth microdilution method. The oil showed good inhibitory effects against C. glabrata and C. tropicalis at minimal inhibitory concentrations ( MIC s) of 0.09 and 0.375 mg/ml, respectively.