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Synthesis and Antidiabetic Activity of 5,7‐Dihydroxyflavonoids and Analogs
Author(s) -
Chang LiuShuan,
Li ChunBao,
Qin Nan,
Jin MeiNa,
Duan HongQuan
Publication year - 2012
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201100049
Subject(s) - chemistry , moiety , flavonoid , in vitro , metformin , structure–activity relationship , biological activity , stereochemistry , traditional medicine , biochemistry , pharmacology , diabetes mellitus , antioxidant , endocrinology , biology , medicine
Abstract In a study to evaluate the structural elements essential for the antidiabetic activity of flavonoids, we synthesized two series of flavonoids, 5,7‐dihydroxyflavanones and 5,7‐dihydroxyflavones. In a screening for potential antidiabetic activity, most of the flavonoids showed a remarkable in vitro activity, and compounds 1f, 2d , and 3c were significantly more effective than the positive control, metformin. The biological activity was mainly affected by structural modification at the ring B moiety of the flavonoid skeleton. The results suggest that 5,7‐dihydroxyflavonoids can be considered as promising candidates in the development of new antidiabetic lead compounds.